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MAMs not only structurally connect the endoplasmic reticulum and mitochondria, but are also rich in a variety of functional proteins related to lipid metabolism such as acyl-coA:cholesterol acyltransferase-1 (ACAT1/SOAT1), acyl-CoA:diacylglycerol acyltransferase 2 (DGAT2) (Ma et al., 2021b), and phosphatidylethanolamine N-methyltransferase (PEMT) (Zhao et al., 2009)

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Semaglutide is the seventh GLP-1 receptor agonist on the US market and the third dosed once weekly

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