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Mol Endocrinol 25: 2134-2143, 2011

Some signs that you should extend your current dose period before escalating include diarrhea that occurs more than 3 times daily, diarrhea that has not improved after 3 weeks at the current dose, significant dehydration symptoms (dark urine, dizziness, dry mouth), or diarrhea that is interfering with daily activities or work

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Absolute distinction was obtained by heat treatment of the suspected peptide [124] The fact that N-terminal glutamic acid can cyclize to form pyroglutamate [125] and lower the mass as a result was used by the authors

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