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They appear to be engaging biological pathways that produce durable changes in the cellular and tissue environment that cardiovascular disease depends on to develop and progress

Dapagliflozin added to usual care in individuals with type 2 diabetes mellitus with pre-existing cardiovascular disease: a 24-week, multicenter, randomized, double-blind, placebo-controlled study with a 28-week extension

Regarding average changes in HbA1c levels, tirzepatide demonstrated both non-inferiority and superiority to semaglutide at all doses [80, 81]

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