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We simulated the effect of pifithrin- treatment by multiplying the phospho-p53-dependent production of p21 and MDM2 with k PFT = 0.5, and the amount of phospho-p53 and the phosphorylation rate of p53 with k PFT phos = 0.67 at the time of treatment, because the effect of pifithrin- causes approximately a 50% decrease in p53-dependent transcriptional activation 95 and a 33% decrease in phosphorylated p53 species 93

The standard per-dose stack is 6 units (100 mcg Ipamorelin + 100 mcg CJC-1295), 23x daily, injected subcutaneously on an empty stomach

Eli Lilly has its GLP-1 agonist mazdutide in a Phase II trial for AUD, while Novo Nordisk is testing the effectiveness of semaglutide, an amylin analogue and an FGF21 analogue in alcoholic liver disease

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doi: 10.1016/s0140-6736(66)92982-5 12 DruckerDJ

Nature 2014;515:20915