It is worth noting that GLP-1 receptor agonists show neutral effects on heart failure hospitalisation, unlike SGLT2 inhibitors which demonstrate benefit in this area
Early improvements in bloating are frequently reported
Once opened, handling and disposal should follow internal laboratory protocols
and taking medications exactly as prescribed support tolerability
42% greater weight reduction with RYBELSUS 14 mg than liraglutide 1.8 mg PIONEER 4 study design 1,6 In a double-blind, double-dummy trial with a primary endpoint of mean change in A1C from baseline to 26 weeks, 711 adult patients with type 2 diabetes on metformin alone or metformin with an SGLT-2i were randomized to RYBELSUS 14 mg (n=285), liraglutide 1.8 mg subcutaneous injection (n=284), or placebo (n=142), all once daily
Risk factors for dumping syndrome that were identified included fundoplication surgery within 1 year of age, presence of severe scoliosis, microgastria, and major cardiac abnormality (41)