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To evaluate whether these changes will affect the metabolic profiles induced by hemin, we measured SAM and SAH levels, where SAM accumulation by hemin was reduced by DMF treatment (Fig

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They are involved in reactive oxygen species (such as superoxide anions, hydrogen peroxide, and hydroxyl radicals) and lipid peroxidation product (such as malondialdehyde, 4-hydroxynonenal, F2-isoprostane, leukotriene) detoxification generated during mitochondrial respiration

Glutathione helps break down alcohol endogenously via a process known as conjugation 25

In intact cells, activation of NFT yielded a radical anion, which subsequently initiated nuclear-factor-erythroid 2-related-factor-2 (Nrf2)-dependent induction of glutamate cysteine ligase (GCL)