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Retatrutide addresses this indirectly by reducing body fat, which is a major source of pro-inflammatory cytokines

Increased antibacterial antibodies are common in patients with CD 213 and antibiotic treatment leading to reduced bacterial diversity and numbers is anti-inflammatory (e.g., downregulating the expression of NF-B, TGF and SMA in the intestinal wall) 214

Low food intake can be a problem, especially in debilitated patients or those who have been hospitalized for long periods

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