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Exclusion criteria included previous participation in this study, treatment with an investigational drug 30 days prior to enrolment, mental incapacity, and unwillingness or language barriers preventing understanding or cooperation

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Moreover, estrogen was reported to regulate proteolysis through the induction of protease inhibitors, preventing excessive degradation of extracellular matrix components that are essential for tissue repair (Horng et al., 2017)

There are two main caspase-dependent apoptotic pathways of apoptosis: the intrinsic pathway and the extrinsic pathway

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