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This clinical comparison breaks down when to choose one over the other, what each does for energy, muscle, and brain function, and what happens when patients use both.

Patients taking Ozempic should seek immediate medical attention (by calling 999 or attending A&E) if they experience: Signs of a severe allergic reaction , including difficulty breathing, swelling of the face, lips, tongue or throat, or severe skin rash Severe hypoglycaemia with inability to swallow, seizures or loss of consciousness (particularly relevant for those on insulin or sulfonylureas) Ongoing seizures or loss of consciousness Patients should contact their GP or NHS 111 urgently if they experience: Severe, persistent abdominal pain that may radiate to the back, potentially indicating pancreatitis stop taking Ozempic and seek urgent assessment Persistent vomiting or diarrhoea lasting more than 24 hours, which may lead to dehydration Symptoms of dehydration , such as extreme thirst, very dark urine, dizziness on standing, or reduced urine output Visual changes , particularly if they have pre-existing diabetic retinopathy Signs of gallbladder problems , such as pain in the upper right abdomen, fever, or yellowing of the skin or eyes For hypoglycaemia (blood glucose below 4 mmol/L): [19] [20] Take fast-acting carbohydrates (e.g., glucose tablets, fruit juice) Follow with longer-acting carbohydrates once symptoms improve Seek medical help if symptoms don't improve or recur Have someone call 999 if unable to swallow or if unconscious Routine follow-up with the prescribing clinician should occur if: Gastrointestinal side effects persist beyond the first few weeks or significantly impact quality of life There are concerns about medication effectiveness or blood glucose control New medications are started that might interact with Ozempic There are questions about injection technique or dose adjustments Patients should never stop Ozempic abruptly without medical guidance, as this may lead to deterioration in glycaemic control

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Very common side effects (affects more than 1 in 10 users): abdominal pain headache urgent or increased need to open the bowels wind with discharge oily discharge fatty, oily stools liquid stools low blood sugar levels (experienced by people with type 2 diabetes) Common side effects (may affect 1 in 10 people): Soft stools bloating (experienced by those suffering from diabetes) rectal pain/discomfort tooth/gum disorder irregularity of the menstrual cycle tiredness Some other orlistat side effects include: allergic reactions changes to your blood tests skin blisters liver or kidney problems pancreatitis gallstones hepatitis bleeding from your back passage inflammation of your bowel How long do orlistat side effects last

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