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Christofk HR, Vander Heiden MG, Harris MH, Ramanathan A, Gerszten RE, Wei R et al

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By suppressing this pathway, natural products like resveratrol, curcumin, and quercetin effectively reduce the bodys production of key inflammatory signals, such as TNF-, IL-6, and IL-1 ( Natural products also exhibit antioxidant effects that reduce oxidative stress by scavenging free radicals, thereby inhibiting inflammation caused by oxidative damage

Experiments both in vitro and vivo have shown that metformin attenuates the progression of DKD by suppressing renal inflammation, oxidative stress, and fibrosis (180)