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GLP-1 receptor agonists like semaglutide (Wegovy) and liraglutide (Saxenda), along with tirzepatide (Zepbound), are FDA-approved medications for chronic weight management that work by regulating appetite and metabolism

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These spaces between intestinal cells vary in size depending on their position along the villi, with larger openings at the base of the villi or the crypts, and smaller openings at the tips of the villi, with recent data supporting the concept that the permeability and composition of the junctions between Paneth cells, goblet cells, stem cells, and other cell types populating the villus-crypt axis may vary widely [7, 32]

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Moreover, DSS triggered apoptosis in both genotypes, as evidenced by elevated levels of activated Caspase 3 (Fig