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By acting on MT1 and MT2 receptors located on hypothalamic GnRH neurons, the pituitary gland, and the ovaries, it participates in regulating pulsatile GnRH secretion, the release of gonadotropins [luteinizing hormone (LH) and follicle-stimulating hormone (FSH)], and ovarian steroidogenesis (75, 76)

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In summary, we present a comprehensive study of a molecule as a putative treatment for obesity, from the design, characterization, preclinical validation, mechanism of action to a phase 1A/B human clinical study

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Toxicol Appl Pharmacol 128:199206 Lenkowski JR, Raymond PA (2014) Mller glia: stem cells for generation and regeneration of retinal neurons in teleost fish

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