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What makes our CJC-1295+Ipamorelin special is an amino acid substitution that is designed specifically to resist rapid enzymatic breakdown allowing for short, transient bursts of receptor activity rather than the continuous binding that comes with DAC (Drug Affinity Complex) compounds
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Val3-Asp4 interact with similar residues at the base of the binding cavity to those observed for residues 2 and 3 of the other peptides, however, with the exception of Y148 1 .43 , these were very transient (Supplemental Table 3)
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