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Sleep Quality Metrics Sleep latency time to fall asleep (track nightly) Sleep duration and wake episodes total sleep time and number of awakenings Subjective sleep quality 1-10 scale, recorded each morning before coffee Wearable data if available, track deep sleep percentage, HRV during sleep, resting heart rate trends Circadian consistency whether waking and sleeping times are becoming more consistent Blood and Biomarker Testing Telomere length testing commercial tests available (e.g., via qPCR or Flow-FISH)

7 Glycaemic effects SUs reduce fasting glucose by 24 mmol/L, decreasing HbA 1c by 1122 mmol/mol when added to lifestyle measures

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People who are discontinuing alcohol, benzodiazepines, or antiepileptic drugs abruptly should also avoid Contrave