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The anti-CD3ef(ab)2 antibody fragments were immobilized onto the NP surface, exploiting CD3 receptor-mediated uptake to optimize T-cell specificity, ultimately augmenting T-cell viability and tumoricidal function

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de Jong SC, Stehouwer CD, van den Berg M, Kostense PJ, Alders D, Jakobs C, Pals G, and Rauwerda JA (1999b)