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Phase 2 trial establishing 24.2% mean weight loss at 12mg over 48 weeks, with dose-response data across the 1mg to 12mg range

Activation of the GPX4 pathway is protective against IR-induced ferroptosis Enhancing GPX4 activity has been the most widely pursued mechanism to prevent tissue injury by IR, successfully mitigating IR-induced ferroptosis in the intestine, liver, lung, ovaries, skin, and CNS tissues (Table 2)

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[DOI] [PubMed] [Google Scholar] 73.Jennings SV, Slee VM, Zack RM, Verstovsek S, George TI, Shi H, et al

For instance, leucine and cystine are crucial in melanoma (13) and von Hippel-Lindau (VHL)-deficient renal cell carcinoma, respectively (14,15)