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The plasma protein binding of DXd is about 98%, with a whole blood/plasma concentration ratio of about 0.6

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Heerspink HJL, Sattar N, Pavo I, Haupt A, Duffin KL, Yang Z, Wiese RJ, Tuttle KR, Cherney DZI

These effects were associated with increased F-actin formation and activation of focal adhesion kinase (FAK) and paxillin phosphorylation, signaling events central to cell attachment and cytoskeletal remodeling during tissue repair processes [4]