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Drug addition was cumulatively or non-cumulative as described in the figure legend

Maintain adequate hydration by drinking 6-8 drinks daily (approximately 1.2-1.5 litres), sipping water frequently throughout the day

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Levothyroxine: Total thyroxine (i.e., adjusted for endogenous levels) AUC of was increased by 33% following administration of a single dose of levothyroxine 600 mcg concomitantly administered with oral semaglutide

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