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Selective GH Release No ACTH or Cortisol Effect Unlike GHRP-6 and GHRP-2, which both resulted in elevated plasma ACTH and cortisol levels in swine models, Ipamorelin did not release ACTH or cortisol at levels significantly different from GHRH stimulation alone even at doses more than 200-fold higher than the ED50 for GH release

But, similar research also indicates that tumors are made less susceptible to chemotherapy, a common cancer treatment due to glutathione

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Synergistic GHRP Combination Moderate Research Extensive research demonstrates that CJC-1295 produces synergistic effects when combined with growth hormone releasing peptides such as Ipamorelin or GHRP-6, resulting in substantially greater GH release than either compound alone