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Protein concentration was 0.4 mg/ml

In addition to the common core mechanisms for regulating the balance of Th17/Treg, several treatment methods discussed in this article involve the same signaling pathways, which are summarized in Table 11

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This balance, however, will be disrupted if there is an increase in ROS production or a decrease in cell antioxidant capacity, resulting in oxidative stress ( As the energy factories of cells, mitochondria are the main sites for the generation of ROS, in which the electron transport chain (ETC) is a prime source for ROS ( The antioxidant capacity of various cellular defense systems is based on enzymatic antioxidants such as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px), and non-enzymatic antioxidants such as ascorbic acid (vitamins C), uric acid, tocopherol (vitamins E), quinols, carotenoids, and polyphenols

He/she has symptoms that can be life-limiting, can impair social activities and proper development, and can be a source of significant stress for other family members