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[10] [11] [12] In the TMD domain a fulcrum of polar residues regulates the biased signaling of the receptor [10] while the transmembrane helical boundaries [13] and extracellular surface are a trigger for biased agonism

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doi: 10.1111/jan.2018.74.issue-5 6 MoulacMAouatiOCarlettiGPelsyFvan den BosSKirkSFLet al