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In vivo , ellagic acid significantly ameliorates CIA in male Wistar rats when administered orally at 25, 50, and 100 mg/kg/day for 21 days, with 50 mg/kg/day identified as the optimal dose

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The following day, the cells were treated with 10 M CMFDA for 1 h, then fixed in 4% paraformaldehyde/4% sucrose in PBS (15 min at RT)