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Regarding long-term clinical trial data on patient outcomes such as the frequency of exacerbations, quality of life, need for lung transplantation, and mortality, these remain more limited (85, 86)

At therapeutic levels in the blood, approximately 90% of paracetamol is broken down into non-toxic metabolites through sulfidation and glucuronidation pathways and then renally excreted[27]

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This makes it difficult to extrapolate optimal research concentrations

2b) lowered endogenous H 2 S levels (Extended Data Fig