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Diclofenac and eugenol hybrid with enhanced anti-inflammatory activity through activating HO-1 and inhibiting NF-B pathway in vitro and in vivo
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On the graphs depicting pooled data, the currents recorded on oocytes were expressed as fractions of the maximal current obtained on NMDA receptorsexpression obtained by applying a combination of glutamate and glycine, both at 10 M ( 3-Measurement of GSH Content Changes in the cellular content of GSH were measured after monobromobimane (mBrB) labeling as previously described ( 3 , 1.25 mM NaH 2 PO 4 , 1 mM CaCl 2 , 2 mM MgSO 4 , 10 mM D-glucose, and 10 mM HEPES (pH: 7.4)
Pregnancy and breastfeeding are clear contraindications - we lack sufficient safety data on high-dose IV administration during these times
doi: 10.1186/ar3046 154 LouveauA.SmirnovI.KeyesT
Quirico L, Orso F, Cucinelli S, Paradzik M, Natalini D,Centonze G, Dalmasso A, La Vecchia S
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