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oral dosing accepts more variability in how much active peptide ultimately reaches the blood

International Journal of Obesity, 39 (12), 17031709

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These results suggested that GLP-1 expression was gradually decreased in CM, and also revealed that although the protein expression of GLP-1R was upregulated after NTG stimulation, the amount of GLP-1Rs that can be activated was decreased, so the activity of GLP-1R in the TNC in CM model was actually inhibited