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Recent inductive techniques, such as NAM and distraction osteogenesis, have improved care over the past decade, and as comparable advances in plastic surgery occur in the future, a child born with a cleft can look forward to fewer operations with better aesthetic and functional results

1c and Supplementary Table 2)

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However, the effect is not universal

(PubMed) The same review warns that systemic administration (IV) may shift melanin production, altering skins natural photoprotection and potentially increasing the risk of UV-induced skin damage or cancer a risk especially relevant in sunny climates

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