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The equivalent arginine-serine network in Rattus norvegicus OAT1 has been implicated in gating dynamics and the allosteric modulation of OAT1 by chloride 25 , with chloride binding to R466 rOAT1 in the inward-facing conformation stabilising this network

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In a series of studies, it was observed that it is possible to increase muscle carnitine concentration if carnitine is given when plasma insulin concentrations are elevated

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