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Morphological and functional metabolism studies link chronic pain and depressive disorders to dysfunctional neuroplastic changes in fronto-limbic brain regions that control emotional responses to painful injuries and stressful events

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Identified metabolites were subjected to functional annotation and classification using databases include Kyoto Encyclopedia of Genes and Genomes (KEGG), Human Metabolome Database (HMDB), and LIPID MAPS Database, to understand the functional characteristics and classification of different metabolites

(Source 2) Tomatoes, and other nightshade vegetables, originated in Central and South America

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