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In oncology, GLP-1R-targeted nanoplatforms enable highly specific delivery of cytotoxic agents to receptor-expressing tumors, minimizing off-target toxicity while addressing chemoresistance

A primary limitation is its poor bioavailability, which arises from its low solubility and rapid metabolism in the liver ( Moreover, despite promising preclinical data, the lack of large-scale clinical trials hampers our ability to establish optimal dosages, long-term safety, and the full range of potential side effects

However, participants doses went up to 3 mg the maximum dose of Saxenda , not Victoza

R package version 0.10.0 (2025)

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By following these steps, patients can manage this side effect more effectively and maintain their quality of life