Method of Administration: Ozempic is administered by subcutaneous injection (under the skin)
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Zepbound (Tirzepatide) Zepbound, a notable choice for weight loss, targets both GLP-1 and GIP hormones, enhancing weight loss outcomes
It is available in both brand and generic forms, although the 8 mg dose is only available as a brand-name drug
(NHS Inform) Long-term considerations: GLP-1 medications can lead to loss of muscle and bone mass due to overall weight loss
Moving forward, the results of the phase 3 SURPASS clinical trial program demonstrated that tirzepatide was as effective and safe as other anti-diabetic agents, such as semaglutide and dulaglutide (SURPASS-2) (SURPASS J-mono), long-acting insulin analogs (degludec and glargine) (SURPASS-3,4), and placebo (SURPASS-1) (SURPASS-5), in managing T2DM diabetes [65,66,67,68,69]