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The hydrophobic staple motif consists of a specific i,i+5 hydrophobic interaction between a residue (N) that precedes the N-cap residue and a residue (N4) located within the 6-helix

Lalor, G., Vutchkov, M., & Bryan, S

95% CI: 5.25, 1.98

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You may not be a candidate if you: Are pregnant or breastfeeding Have active or hormone sensitive cancer Have uncontrolled endocrine conditions Are medically unstable or non compliant Are looking for a shortcut instead of a plan Certain peptides require extra caution depending on your history

The wolfram-like variant wfs1(E864k) destabilizes mam and compromises autophagy and mitophagy in human and mice