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An authoritative review of B12 deficiency from the clinical perspective

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It prompts the pancreas to secrete insulin, suppresses glucagon, slows gastric emptying so food stays in the stomach longer, and acts on receptors in the hypothalamus and brainstem to reduce appetite

When folate cycling is impaired by MTHFR insufficiency, the dihydrofolate THF step accumulates dihydrofolate, competing with the BH2 BH4 reduction step for DHFR activity and NADPH

These results are not surprising as SGLT2 inhibitors and GLP-1RA have different mechanisms of action

It is also causing to lower the blood pressure