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0.2 mg/kg liraglutide (Tocris) was intraperitoneally injected to the treatment group 45 minutes before the tolerance tests (-45 min)

Mazdutide, targeting GLP-1 and glucagon (but not GIP), reaches about 14-20% weight loss depending on dose and trial duration

Contemporary scientific investigations have validated the fact that traditional botanical drugs and their formulations derived from TCM and TM possess distinctive benefits for preventing and treating HACE by modulating mechanisms such as anti-hypoxia, hypoxic pulmonary hypertension reduction, angiogenesis and vasoconstriction inhibition, decreased blood-flow resistance, reduced cell permeability, inflammatory response alleviation, and anti-oxidative stress (Jiang et al., 2022

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Elevated adiponectin concentrations have been noted in major clinical trials with GLP-1RAs (123, 188) and, more robustly, with tirzepatide (189)

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