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Thus, the authors concluded that resveratrol is able to ameliorate the psycho-behavioral alterations induced by estrogen deficiency through suppression of inflammatory mechanisms and to be effective in the alleviation of postmenopausal changes [85]

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The peptide has an arginine in place of glutamic acid at position 3, and an extra 13-amino-acid extension on the front (the N-terminus ), making the full chain 83 amino acids instead of native IGF-1's 70