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In the SURMOUNT-1 study, a phase 3 clinical trial in obese patients, randomized participants in a 1:1:1:1 ratio to tirzepatide (5, 10, 15 mg) or placebo over 72 weeks, significant weight reductions were observed at 72 weeks: 15.0% for 5 mg, 19.5% for 10 mg, 20.9% for 15 mg, compared to 3.1% for placebo [18]

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The success of GLP-1/GIP and GLP-1/GCG dual agonists thus far suggests that GLP-1/GIP/GCG may provide even greater WL compared to dual agonist therapies

New agents, such as tetrathiomolybdate salts, are currently being investigated in clinical trials, and genetic therapies are being tested in animal models

The peptide market has expanded rapidly, but not every supplier follows the same standards