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doi: 10.1021/acs.jafc.2c03800 44 SunY.FengX.LiY.LvJ.ChengD.LuY.GaoD.et al

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While others have reported on the significant MACE reduction with GLP-1RA therapy in the secondary prevention cohort, but not in the primary prevention setting [91], our findings extend the current notion that the beneficial impact on the individual MACE constituents, particularly MI risk reduction, may be attenuated in the higher risk secondary preventative population with established CVD, often characterized by advanced age and multimorbidity status [90]