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Not all patients will qualify for treatment

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contributed to the critical review, editing, and revision of the manuscript for important intellectual content and approved the final version

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The relevance of both GLP-1R and GCGR in the effects of G49 during 1-week treatment in reducing body weight and adiposity was reinforced by an alternative experimental approach in which receptors were blocked with monoclonal antibodies (mAb)

The signaling pathway involving receptor activator of nuclear factor-B ligand (RANKL), its receptor (RANK), and osteoprotegerin (OPG) plays a pivotal role in the regulation of bone resorption