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Combination chemotherapy can significantly improve the efficacy and does not increase toxicity

Similarly, chemogenetic activation of this circuit reversed morphine-induced constipation in mice, including significantly increased the output and water content of feces, as well as a significant higher transit rate and motility of the small intestine in hM3Dq-expressing mice than mCherry-expressing controls (Supplementary Fig

This prevents the common mistake of attributing weight changes to medication effects when they actually result from dietary shifts during transitions

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