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doi: 10.1111/exd.13250

Some IGF-1 derivatives, such as the GPE derivative, made up of just the last three N-terminal amino acids of the IGF-1 protein, have been shown to have therapeutic effects in neurological injuries like stroke

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Landmark trials including STEP 1 through STEP 5 demonstrated semaglutide's efficacy for weight reduction, with participants achieving 10-22% body weight loss depending on dose and study duration

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Impaired cerebral autoregulation and the other metrics of cerebral hemodynamics reported by Koch et al (rapid rise in MCA pulsatility, drop in cerebrovascular resistance index) in the immediate post-exercise period align well with the phenomenon of weightlifters blackout in which individuals may experience syncope or pre-syncope immediately following high intensity resistance exercise, particularly when in the upright standing position due to the sudden pressure drop upon release of the external load (Koch et al., 2005)