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Our group recently identified oxamic hydrazide as a potent CSE inhibitor by screening a large chemical library of 161,600 compounds ( 50 value of 13 M with high selectivity over other PLP-dependent enzymes including CBS, alanine aminotransferase and methionine -lyase
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This combination is highly prized for its targeted, pulsatile stimulation of endogenous Growth Hormone (GH) release, making it a crucial subject for studies targeting tissue repair, body composition, and overall recovery
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doi: 10.1016/j.taap.2008.11.007 243
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