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And while both semaglutide and tirzepatide can lead to significant weight loss, they don't work exactly the same way

How we reviewed this article: Phelps Health (2023)

Related resources: IGF-1 LR3 Profile | IGF-1 LR3 Dosage Protocol Anti-Aging and Longevity Peptide Dosages These peptides target the mechanisms that make your body age: collagen loss (wrinkles, joint stiffness), telomere shortening (cellular aging), and mitochondrial decline (low energy, metabolic slowdown)

When it does happen, it's usually because of rapid weight loss, not getting enough nutrients, or stress on the body, rather than the drug itself

Adding 30 minutes of walking, resistance training, or any physical activity increases your TDEE and allows a higher calorie target while maintaining the same deficit