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Under ER stress, the integrated stress response (ISR) pathway is activated, leading to the phosphorylation of eIF2 and subsequent upregulation of ATF4, a transcription factor that increases CHAC1 expression

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The activation of CHAC1 by this pathway leads to increased apoptosis, as evidenced by its role in enhancing apoptosis markers such as TUNEL, PARP cleavage, and AIF nuclear translocation

CrossRef Incretin-Based Therapies: A Promising Approach for Modulating Oxidative Stress and Insulin Resistance in Sarcopenia Raniah I

Interestingly, many herbal medicinal plants used to treat vitiligo have been implicated in inducing the Nrf2 pathway and related genes