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Short peptides exhibit high penetration capabilities through cellular and nuclear membranes and possess low toxicity

The method employs an alkylation step using N-ethylmaleimide (NEM) to derivatise GSH into GS-NEM, which is more stable for storage and enhances the sensitivity of detection of this derivatised compound by MS

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Additionally, the aged metabolic system displays reduced flexibility, undermining its capacity to efficiently respond to stimuli and recover from damage

doi: 10.1002/1521-4141(2002010)32:10 3.0.CO;2-V

These hormones also influence telomerase activity and cellular senescence pathways, potentially affecting the rate of cellular aging and the accumulation of senescent cells that contribute to age-related dysfunction