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Specificity is the key to increased productivity Unlike insulin, LONG R 3 IGF-I specifically targets and activates the type I IGF Receptor (IGF-IR) resulting in greater activation of downstream signaling cascades responsible for proliferation and inhibiting apoptosis

Pickart estimated lethal dose at approximately 22,500 mg for humans (300-fold above effective doses), with animal LD50 studies in mice showing 8 mg per 25g mouse (320 mg/kg, translating to ~22,400 mg for 154 lb human)

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Exercise and Recovery Oxidative and antioxidant activity is temporarily altered by exercise

Under normal conditions, cells exchange intracellular glutamate (Glu) and extracellular cystine (Cys 2 ) at a ratio of 1:1 through the cystine/glutamate anti transporter (system Xc - )