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By promoting the excretion of these harmful substances and reducing oxidative damage, ALA and R-ALA serve as a therapeutic metal chelating antioxidant

The practical longevity implications require long-term supplementation and are not assessable on short cycle timescales

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Ultimately, the gut microbiota can now be regarded as a crucial distal regulator of OA pathogenesis in many ways including regulation of the intestinal barrier function, effect on immune-inflammatory mechanisms and regulation of host metabolic disorders