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Conversely, CHAC1s role in ferroptosis makes it a potential biomarker and therapeutic target, with studies indicating that its modulation could be leveraged to induce ferroptosis selectively in breast cancer cells, thereby suppressing tumor proliferation and improving patient outcomes

[DOI] [PMC free article] [PubMed] [Google Scholar] 81.Pastori D, Pani A, Di Rocco A, Menichelli D, Gazzaniga G, Farcomeni A, et al

No SAEs were reported among either LCLT or placebo groups

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Protein lysates from fresh human lumbar DRGs from healthy donors, individuals with RA with pain and individuals with RA without pain (AnaBios, Supplementary Table 8) were homogenized with beads using a tissue homogenizer (Qiagen) and processed in a similar way to mouse DRGs