In some GCs, the currents induced by GABA (30 mol/L) were almost completely suppressed (7.09% 4.12% of control, P 0.05, n = 3), but when the exendin-4 concentration was increased to 10, 30, 50, and 100 nmol/L, the GABA currents were suppressed to 74.35% 6.79% ( P 0.05, n = 7) (Fig
The D-Phe inversion sits inside the conserved His-Phe-Arg-Trp message tetrapeptide that every melanocortin receptor recognises, and it is the substitution responsible for the markedly prolonged receptor occupancy reported for this analogue relative to alpha-MSH, because inverting that stereocentre removes a favoured chymotrypsin-like cleavage point
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