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The authors also emphasized that the wider use of these drugs should consider social and commercial determinants of health, including access, affordability and insurance coverage, to avoid deepening existing health inequities among people living with obesity

DOI: 10.1021/jm00394a033 MC4R Pathway Research Pre-clinical studies using MT-2 as an MC4R agonist tool compound have examined its effects on hypothalamic appetite circuits, food intake, body weight regulation, and metabolic parameters in rodent models

doi: 10.1073/pnas.0502402102

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Scientific References Berberine as a Bioactive Alkaloid: Multi-Omics Perspectives on Its Role in Obesity Management