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Garczorz et al 67 found that GLP-1R agonists reduced endothelial cell MMP-1, MMP-2, and MMP-9 production and stimulated TIMP-1 and TIMP-2 synthesis by inhibiting TNF--induced activation of NF-B, suggesting that GLP-1RAs may play a role in the treatment of COPD by altering protease/antiprotease synthesis

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Secondly, Hcy is also important for the synthesis of cysteine via the trans-sulfuration pathway, which leads to the synthesis of glutathione