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Dose-response studies show therapeutic effects from 10 g/kg to 10 mg/kg in rats with no reported adverse events, suggesting a broad therapeutic window that would extrapolate to 50250 mg in humans

Later, the oral one was replaced by the intramuscular formulation, which was also preferred by the patient

Botox is a neurotoxin produced by Clostridium botulinum, and its most commonly recognized for its cosmetic application to reduce fine lines and wrinkles

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AHK-Cu is alanyl-histidyl-lysine copper, a related tripeptide that also binds copper(II)

Furthermore, Erastin-induced ferroptosis in target cells is accompanied by membrane rupture and the release of large amounts of ROS, which may further enhance autophagy via ROS-mediated activation of the AMPK/mTOR signaling pathway